Basil Rigas Selected Research

N- acetyl- S- (alpha- methyl- 4- (2- methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl ester

1/2008	NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis?
6/2006	Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets.
1/2006	Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation.
7/2004	Nitric-oxide-donating NSAIDs as agents for cancer prevention.
6/2004	NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property?
12/2002	Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect.

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Basil Rigas Research Topics

Disease

64	Neoplasms (Cancer) 01/2020 - 05/2002
38	Colonic Neoplasms (Colon Cancer) 10/2014 - 01/2002
19	Carcinogenesis 07/2016 - 03/2003
15	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 12/2002
6	Dry Eye Syndromes (Dry Eye Syndrome) 01/2022 - 01/2018
6	Lung Neoplasms (Lung Cancer) 12/2014 - 12/2002
5	Inflammation (Inflammations) 01/2021 - 07/2006
5	Breast Neoplasms (Breast Cancer) 02/2014 - 09/2011
4	Carcinoma (Carcinomatosis) 04/2006 - 01/2002
3	Colorectal Neoplasms (Colorectal Cancer) 10/2015 - 11/2005
3	Necrosis 01/2009 - 02/2006
2	Glioblastoma (Glioblastoma Multiforme) 12/2019 - 04/2016
2	Ovarian Neoplasms (Ovarian Cancer) 01/2018 - 01/2018
2	Metaplasia 10/2017 - 07/2016
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2014 - 08/2013
2	Arthritis (Polyarthritis) 06/2013 - 09/2012
2	Adenocarcinoma 01/2009 - 04/2006
2	Microsatellite Instability 09/2008 - 11/2007
2	Body Weight (Weight, Body) 01/2008 - 06/2006
2	Intestinal Neoplasms (Intestinal Cancer) 08/2007 - 03/2005
1	Autoimmune Diseases (Autoimmune Disease) 01/2020
1	Alopecia (Baldness) 11/2017
1	Pancreatitis 07/2016
1	Aberrant Crypt Foci 10/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2015
1	Polyps 04/2015
1	Dysbiosis 01/2015

Drug/Important Bio-Agent (IBA)

27	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 07/2016 - 10/2003
23	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2020 - 01/2002
22	Sulindac (Copal)FDA LinkGeneric 07/2021 - 12/2002
22	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2011 - 12/2002
21	nitroxy-butyl-acetylsalicylic acidIBA 06/2011 - 10/2003
15	Pharmaceutical PreparationsIBA 01/2020 - 03/2005
7	2-(4-isobutylphenyl)propionic acid 4-(diethoxyphosphoryloxy)butyl esterIBA 12/2014 - 06/2011
7	NF-kappa B (NF-kB)IBA 03/2010 - 04/2003
6	Ibuprofen (Motrin)FDA LinkGeneric 04/2016 - 12/2002
6	Indomethacin (Indometacin)FDA LinkGeneric 04/2013 - 12/2002
6	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 07/2011 - 11/2003
6	N- acetyl- S- (alpha- methyl- 4- (2- methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl esterIBA 01/2008 - 12/2002
5	OXT-328IBA 01/2022 - 10/2008
5	Valproic Acid (Depakote)FDA LinkGeneric 01/2020 - 01/2013
5	Antineoplastic Agents (Antineoplastics)IBA 12/2019 - 10/2008
5	Biological ProductsIBA 10/2012 - 04/2003
5	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 04/2006 - 11/2003
4	EstersIBA 10/2014 - 03/2009
4	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 09/2014 - 03/2010
4	beta CateninIBA 10/2009 - 10/2003
3	Cyclin D1IBA 04/2016 - 10/2003
3	Drug CombinationsIBA 10/2015 - 07/2011
3	Dinoprostone (PGE2)FDA Link 04/2013 - 07/2005
3	Eflornithine (Ornidyl)FDA Link 07/2011 - 10/2010
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2009 - 04/2003
3	phosphoaspirinIBA 03/2009 - 01/2008
3	EnzymesIBA 10/2008 - 10/2005
3	nitroaspirinIBA 06/2006 - 01/2004
3	Nitric Oxide Synthase (NO Synthase)IBA 10/2005 - 11/2003
2	CytokinesIBA 12/2021 - 01/2012
2	Concanavalin AIBA 01/2020 - 01/2018
2	MDC-1112IBA 01/2020 - 12/2019
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 12/2019 - 10/2013
2	Ethylene Glycol (Monoethylene Glycol)IBA 12/2018 - 10/2017
2	AmidesIBA 04/2016 - 09/2014
2	CateninsIBA 01/2015 - 06/2011
2	Estrogen ReceptorsIBA 01/2014 - 01/2012
2	Interleukin-6 (Interleukin 6)IBA 06/2013 - 01/2012
2	Interleukin-10 (Interleukin 10)IBA 06/2013 - 01/2012
2	HydrogelsIBA 06/2013 - 10/2012
2	Folic Acid (Vitamin M)FDA LinkGeneric 03/2013 - 10/2008
2	F2-Isoprostanes (F2 Isoprostanes)IBA 11/2012 - 09/2011
2	Liposomes (Liposome)IBA 06/2012 - 01/2012
2	ThioredoxinsIBA 01/2012 - 10/2008
2	Annexin A1IBA 01/2012 - 03/2010
2	Flurbiprofen (Froben)FDA LinkGeneric 09/2011 - 06/2004
2	Fluorouracil (Carac)FDA LinkGeneric 09/2011 - 01/2002
2	CalciumIBA 10/2008 - 08/2007
2	PPAR deltaIBA 01/2008 - 02/2006
2	CarcinogensIBA 04/2006 - 04/2006
2	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 10/2005 - 07/2005
2	EicosanoidsIBA 10/2005 - 07/2005
2	TCF Transcription FactorsIBA 11/2003 - 10/2003
1	ChemokinesIBA 01/2021
1	Gemcitabine FDA Link 01/2020
1	Serine (L-Serine)FDA Link 12/2019
1	AcidsIBA 12/2018
1	CeramidesIBA 11/2017
1	Alkaline CeramidaseIBA 11/2017
1	poly(lactide) (polylactic acid)IBA 10/2017
1	poly(lactic acid-ethylene glycol)IBA 10/2017
1	CeruletideIBA 07/2016
1	Glycerol (Glycerine)FDA LinkGeneric 04/2016
1	Trifluoperazine (Stelazine)FDA LinkGeneric 01/2015
1	PrebioticsIBA 01/2015
1	Dopamine Receptors (Dopamine Receptor)IBA 01/2015
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2015

Therapy/Procedure

15	Chemoprevention 01/2018 - 02/2002
3	Injections 07/2016 - 06/2006
3	Drug Therapy (Chemotherapy) 10/2013 - 11/2010
2	Therapeutics 08/2013 - 10/2012
1	Topical Administration 02/2019
1	Ophthalmic Administration 02/2019